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What is Tadalafil?
Tadalafil is in a class of medications known as PDE-5 inhibitors, which are used to treat cases of male impotence. Tadalafil is a fairly new impotence drug and has only just come onto the market.
How does Tadalafil Work?
Tadalafil acts in the same way as sildenafil citrate, by blocking an enzyme called phosphodiesterase-5, or PDE-5. This helps the smooth muscles in the penis relax and widen, which allows for more blood to enter. As a result, you gain erections faster and easier with Tadalafil.
In clinical testing most erectile disfunction sufferers were administered one 10 mg or 20 mg tablets per day.
Tadalafil Info for first time users
Tadalafil can last for two days. Tadalafil starts working faster than sildenafil citrate, sometimes in 16 minutes, and lasts 24 hours or more.In contrast, sildenafil citrate usually works for only four hours after an hour's delay.
Tadalafil can build up in the body
Erectile dysfunction, or male impotence, sufferers using one Tadalafil tablet every two days will find Tadalafil levels go on rising to reach a steady state after about a week. On day 2, when taking a second tablet around 20% of the original tablet is still in the blood stream. On day 4, 22% of a single dose will still remain. On day 6 around 24% and so on. So erectile dysfunction sufferers who find a single dose still has an effect after 36 hours could in theory find that a tablet every other day enables them to have sex whenever they wish without fear of failure - assuming reasonable intervals before doing so.
Tadalafil Side Effects
The most common side effects reported in the study were headache, myalgia (muscle pain), dyspepsia (upset stomach following meals) and back pain. The severities of these side effects were minimized with lower doses.
Tadalafil Drug Interactions
Consult your doctor about all nonprescription and prescription medication you may use, especially any nitrate medications (e.g., nitroglycerin, isosorbide dinitrate), nitroprusside (any "nitric oxide donor" medicines), cimetidine, erythromycin, azole antifungals (e.g., itraconazole, ketoconazole), mibefradil, rifamycins (e.g., rifampin) or high blood pressure medicines. Is Tadalafil Better than other ED treating drugs? Tadalafil comes in smaller doses and produces fewer side effects. Tadalafil also works much faster than other available drugs. In clinical trials, the majority of men who took the drug were able to engage in sexual intercourse within 30 minutes or less. The studies also indicated that Tadalafil stays in the system for up to 24 hours. That's 20 hours difference than the traditional sildenafil citrate treatment
Tadalafil and cardiovascular side effects
The early tests seem to indicate that Tadalafil doesn't affect blood pressure as much as other ED drugs. The clinical trials showed that statistically there was no significant difference in cardiovascular side effects from the placebo.
According to clinical studies data on Tadalafil, men with erectile dysfunction, or male impotence, reported a statistically significant improvement in successful intercourse attempts at 24 and 36 hours after taking the drug, compared to placebo. Other new findings including a summary of cardiovascular safety data showed no increased incidence of cardiovascular events during clinical studies. In all studies, compared with placebo, use of Tadalafil demonstrated consistent and statistically significant improvement and the treatment effect did not diminish over time.
Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep it out of the reach of children.